Supplementing with PEA has been scientifically shown to naturally assist in the reduction of inflammation and to have neuro-protective and possibly pain control effects. This natural anti-inflammatory supports abnormal immune responses and the nervous system.* It does not block pain signals the way opioids and other analgesics do. Instead it works upstream by supporting the healthy function of glial cells and mast cells. Glial cells are responsible for facilitating nerve impulses, and exerting an inflammatory response on neurons. Overactive glial and mast cell activation induces an increase in the density and sensitivity of pain receptors and can play a part in a variety of chronic pain disorders. PEA downregulates those overactive cells. Because PEA tends to combine with or dissolve in lipids or fats, I recommend that you take it with some food or milk.