This formula is an optimal methylation formula with activating co-factor to provide sufficient folinic acid and methyl folate (5-MTHF) support the methylation pathway. This product is designed to be used in conjunction with the Methylation Pro Topical OR Methylation Complete Fast Dissolves that provides the activating B12 co-factors to deliver the additional tetrahydrofolate to support immune and neurological recovery. Methyl groups are essential for normal DNA cell replication! They literally turn genes “on” or “off.” “Bad” genes can lead to birth defects, depression, cognitive decline, diseases and cancer and can be expressed by a depletion of your body’s methyl groups.