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Genomix Nutrition: Methylation Markers

As we talked about in our original conversation about Genomix Nutrition there are five different important categories to look at when it comes to your genomic report: Neurotransmitter, Methylation, Mitochondria, Detoxification and Inflammatory markers. In the last blog we talked about neurotransmitter genetic markers. Now let’s talk about methylation and methylation genetic markers. Here are your most important methylation markers:

MTHFR: C 677T,

MTHFR: A 1298C,





  • The simplest way to define methylation is a process in which certain chemicals called ‘methyl groups’ keep various constituents such as proteins, DNA and other molecules in good ‘working’ condition. For example, if the ‘feel-good’ brain chemical serotonin is not methylated it will become inactive which in turns leads to depression!

    As we age the methylation processes in our bodies start getting ‘tired’ and become less efficient. Therefore, if you have the MTHFR SNP, for example, and don’t take steps to ensure balanced methylation by taking Methylated Folic Acid, then any hope of a long life free of degenerative diseases is an unlikely possibility. If your body’s methylation is not working at an optimal level it will translate into many different health problems and will accelerate your aging process. In fact, if methylation would stop altogether you would die in just a few days!

    Methylation is key to making all the chemicals in our bodies. The following are just a few of the vital functions:

    • It is used to stop certain viruses that can damage the DNA. When DNA is destroyed cells would not be able to make proteins, repair themselves, or replicate. Not good!

    • On the other hand, it suppresses replication of DNA in areas where the body does not want it replicated.

    • Extremely important for neurological chemicals such as serotonin and dopamine.

    • Extremely important for formation of some chemicals in the blood.

    • It inactivates replication of the X chromosome, which is very important.

    • It is used to cause a genetic trait to come from only one parent, and not both.

    • It prevents some genetic diseases.

    • It helps protect the tags or telomeres on the genes. These are strands of DNA at the ends of each of your chromosomes, the older we get the shorter they get.

    • Primary method of removing toxins in the phase 2 liver detoxification system of the body

    • Involved in balancing hormones, such as restoring the proper balance of estrogens, for example

    • Helps adaptive energy production greatly. Without adequate methylation, one becomes very tired.

    • Required to make coenzyme Q10. This important substance is needed for heart health and for energy production within the mitochondria. 

    If you have any of the SNPs mentioned above, you have a greater risk of poor modulation. The B Vitamins, B6, B12 and folic acid, plus Tri-Methyl-Glycine TMG, (also known as Betaine), and SAMe are vital for methylation. Methyl Folate Plus, Methylation Complete or Neuroimmune Stabilzer cream are a lifelong regimen for the poor methylator.